Advancing cardiovascular innovation
There are many different kinds of cardiovascular disease, which affect over 17 million people worldwide1. The global cardiovascular disease (CVD) pharmaceutical market alone is forecast to grow to some US$ 107 billion by 20182 , while the US$ 200 billion3 medical device market (diagnostic, therapeutic and monitoring) is led by CVD sales. Of the new therapeutic pharmaceuticals being developed, the highest proportion is for CVD4.
THE FIRST STENTS AND THE WORLDWIDE FIRST BALLOONDILATATION OF A CORONARY ARTERY TO TREAT CORONARY ARTERY DISEASE WERE INVENTED AND DEVELOPEDINOUR REGION
Within this global market, companies and re searchers in the BioAlps cluster have contributed significantly to the market.The first stents and the worldwide first balloon dilatation of a coronary artery to treat coronary artery disease were invented and developed in our region. The innovations in technology and design of cardiovascular devices such as artificial hearts, bioresorbable stents, tissue heart valves and heart rhythm devices with wireless telemetry features are driving the cardiovascular de vices market. Surgery has become less and less invasive, driven by such centres of excellence as the Geneva University Hospitals (HUG) and the Bern University Hospital (Inselspital).
As the burden of CVD grows with ageing populations and more sedentary lifestyles, research continues apace. AtheroRemo5 , a 7th Framework Collaborative Project based in Geneva, is carrying out basic and clinical research focused on inflammatory processes and immunity in atherosclerotic cardiovascular diseases. Uniquely poised to draw on the multidisciplinary expertise in the region, ARTORG Cardiovascular Engineering (ACE)6 is a joint research organisation in which expertise in biomedical engineering research, clinical research and clinical medicine converge to find new ways to diagnose and treat CVD. ACE is part of the newly founded Artificial Organ (ARTORG) Center for Biomedical Engineering Research at the University of Bern. The Departments of Cardiovascular Surgery and Cardiology (Inselspital, University Hospital Bern) and the Medical Faculty of the University of Bern are the clinical partners of ACE.
Two of the major multinational players in the CVD field chose the region to house their European headquarters, Medtronic and Edwards Lifesciences. Several dynamic startups have profited from the interdisciplinarity available in the region, notably Endosense, which has developed the first force-sensing catheter for atrial fibrillation ablation.
3. Extrapolation from http://www.marketsandmarkets.com/Market-Reports/medical-devices-market-403.html
4. IFPMA, The pharmaceutical industry and global health, 2011
Symetis is a privately held Swiss company developing new transcatheter aortic valve implantation (TAVI) solutions for all access: transapical, transfemoral and transaortic.
TAVI is recommended for high-risk patients with severe aortic stenosis and not eligible for conventional open-heart surgery.
Led by serial entrepreneur Jacques Essinger, Symetis is targeting the ca. $2 billion TAVI market. The company’s products, ACURATE TA™ and ACURATE TF™, are composed of a porcine biologic valve attached to a self-expandable nitinol stent which features a unique self-seating, self-sealing design, realising straightforward implant procedures, better results and fewer TAVI complications.
In post market studies, ACURATE TA™ has demonstrated a high procedure success rate, superior safety profile and minimal PV leak.
Symetis’ ACURATE TA™ Transapical Aortic Bioprosthesis has been granted CE Mark in 2011 and the ACURATE TF™ transfemoral device, is currently in CE Mark trial phase and is expected to receive approval by the end of 2013.
Linking cardiology with other discoveries
As cardiovascular disease is often linked to other pathologies, cardiology benefits from cutting edge research in related diseases, as well as from the array of micro- and nanotechnologies in the BioAlps region. The combined strength of the region’s research institutions, teaching and research hospitals, and technology centres, provide an environment conducive to research and development, resulting in world premières such as stents.
The lists below are non exhaustive and showcase some examples of the work being done in the region Find more information in our extensive databases: bioalps.org/community and, for the six alpine regions, alpslifesciencesearch.com
Academic institutions at the forefront of cardiology in western Switzerland
Geneva University UNIGE
Department of Medicine, Cardiovascular
Heart rhythm, atrial fibrillation, heart flutter
Geneva University UNIGE & Geneva University Hospitals HUG
Inflammatory processes of and immunity in atherosclerotic cardiovascular diseases
Biodegradable prostheses, atherosclerosis and heart attack research, clinical research, ablation techniques, cardiac imaging
Ecole Polytechnique Fédérale
de Lausanne EPFL
Biomedical Imaging Group
Multiscale motion mapping, positron tomography, stress echocardiography
Embedded Systems Lab
Miniaturisation of heart monitoring systems
University of Bern UNIBE &
University Hospital Bern (Inselspital)
ARTORG Centre for Biomedical Engineering and Research
Cardiovascular engineering research, functional diagnostics, interventional treatment of cardiovascular diseases. Ventricular assist devices
Swiss Cardiovascular Centre (CVRC)
Cardiac collateral circulation, cardiac transplant, cardiomyocyte biology, angiology, ion channels and channelology, ischemia, reperfusion
University of Lausanne UNIL & University Hospital of Lausanne CHUV
Faculty of Biology and Medicine (FBM) Cardiovascular Assessment Facility (CAF)
Animal and cellular models of CVD
University Hospital of Lausanne CHUV
Cardiomet (Cardiovascular and Metabolism)
Cardiovascular disease, rhythm disorders, echocardiography, interventional cardiology, molecular cardiology, cardiac transplants
University of Fribourg UNIFR
Faculty of Science and Medicine
Cardiovascular physiology and vascular biology
Sample list of large and small cardiovascular companies in the Bioalps cluster
Marker bands, endoscope tubes, implantable alloys, diagnostic biopsies, breakable canulae
Drug-eluting stents, Drug-coated stents, bare metal stents and angioplasty catheters
Transcatheter aortic valves for transapical, transfemoral and transaortic implantation
The fact sheet provides a view of the key players in the sector at any given time; it is not comprehensive and is subject to regular updates.
This current edition was produced in Autumn 2019.