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Immunology is the complex and exciting branch of biomedical science concerned with the physi ological responses of the body’s immune system, the recognition of self and not self, and all the biological, serological, and physical chemical ef fects of immune reactions. The field covers au toimmune disease, hypersensitivities, immune deficiency and transplant science among others.

IT IS NO SURPRISE THAT THE BLOCKBUSTER DRUG TO TREAT MULTIPLE SCLEROSIS, REBIF ® , WAS DEVELOPED IN WESTERN SWITZERLAND.

One of the most diverse and dynamic biopharma ceutical market, immunology is forecast to reach over $138 billion in worldwide sales by 2016, with a compound annual growth rate (CAGR) of 2.3 percent and is expected to account for nearly 20 percent of the global pharmaceutical market by 20161. Recent bibliographic studies rank Swit zerland first for the number of publications in immunology, and second and third respectively in molecular biology and pharmacology2, dem onstrating the vibrancy of research in the country. It is no surprise that the blockbuster drug to treat multiple sclerosis, Rebif®, was developed in Western Switzerland.

Emerging diseases, micro-organism drug resist ance, as well as personalized medicine and chang ing public health priorities provide a wealth of op portunity in the immunology field. The BioAlps region is uniquely poised, with its combination of fundamental research and applied sciences, to bring to market innovations in diagnostics, vac cines, monoclonal antibody and drug therapies.

The field of immunology converges with the field of oncology and research in the NCCR Molecular
Oncology3 and the Ludwig Institute for Cancer Research, which are researching tumour im munology and immunity, and cancer immuno therapy. Multinational companies such as UCB Farchim, who recently built a CHF 300 million production unit in the region, and Merck, market leading products in immunology, notably autoimmune disease, which are manufactured in state-of-the-art facilities in Switzerland. Founded by the previous head of Nestlé Global Research, the start-up AC Immune is developing innovative therapeutics with “best in class” potential against Alzheimer´s Disease and other conformational dis eases along three axes: vaccines, antibodies and small molecules.

NovImmune, founded by cDNA cloning inventor Bernard Mach, specializes in discovering and de veloping compounds to treat the underlying caus es of inflammatory diseases and immune-related disorders and AC Immune is a biopharmaceutical company and a leader in Alzheimer’s disease (AD) drug development, developing innovative therapeutics against AD along three axes: vaccines, antibodies and small molecules, was elected by the World Economic Forum as Technology Pio neer 2009 for its accomplishments as an innova tion leader and for its breakthrough technologies.

It is this particular blend of academic knowhow and commercial savvy that is the reason why mo lecular diagnostics and point of care testing are specialties of the region, with companies like Abi onic, Augurix and Biocartis working closely with leading academic institutions to leverage knowl edge and science.

The Swiss Institute of Bioinformatics (SIB) man ages several bioinformatics core facilities that help scientists around the world conduct their research and analyse their data, helping scientists under stand cellular biology and systems.

2JBC Cover Art ACI-24_20110321

AC IMMUNE Leader in precision medicine of neurodegenerative diseases

Co-founded in 2003 by CEO Prof Dr Andrea Pfeifer, recognized in 2009 as Technology Pioneer by the WEF and other recognitions such as the BioAlps Award 2013, AC Immune is dedicated to improve the lives of patients suffering from Alzheimer’s and other neurodegenerative diseases. AC Immune closed with their partner Genentech an exclusive outlicensing agreement ($300 million) for its anti-Abeta antibody in 2006 and a second exclusive worldwide license agreement, research and commercialization collaboration for anti-Tau antibodies ($418 million) in 2012 and a licensing agreement for anti-Tau therapeutic vaccine ($509 million) with Janssen Pharmaceuticals in 2015. Following its initial public offering on the NASDAQ in 2016, they raised approximately another USD 57.8 million. The Company’s pipeline features nine therapeutic and three diagnostic product candidates to address a broad spectrum of neurodegenerative indications to prevent and modify diseases caused by misfolding proteins, such as Alzheimer’s disease with four candidates in clinical trials.

Ground-breaking research leads to the market

The complex field of immunology benefits from the cutting edge research available in Western Switzerland, offering the opportunity to discover new products. The combined strength of the region’s research institutions, teaching and research hospitals, and technology centres, provide an environment conducive to research and development, with to bring new diagnostics, vaccines and treatments to world markets.

The lists below are non exhaustive and showcase some examples of the work being done in the region.

Find more information in our extensive databases: www.bioalps.org/community and, for the six Alpine regions, www.alpslifesciencesearch.com

Academic institutions at the forefront of immunology in western Switzerland

Geneva University UNIGE

Department of Pathology and  Immunology

Cell biology, T-lymphocytes, growth factors, role of interleukin, general immunology and immunopathology

University Hospital Geneva HUG

Department of Medical Specialties, Division of Immunology and Allergy

Immunologic mechanisms and clinical outcome associated with living donors, ABO-incompatible grafts and xenotransplantation

Ecole Polytechnique de Lausanne EPFL

Global Health Institute

Host-pathogen interactions, innate and acquired immunity, HIV, tuberculosis and malaria

University of Bern UNIBE and University Hospital Bern (Inselspital)

University Institute of Immunology

Antbodies, antigens, growth factors

B-cell, antibody, T-cell and lymphokine research

University of Lausanne UNIL and Ludwig Institute for Cancer Research LICR

The Ludwig Center for Cancer Research of the University of Lausanne (LICR@UNIL)

Cancer immunobiology and immunotherapy

University Hospital of Lausanne CHUV

Immunology and Allergy Research (IAL) and

Antiviral immunity, tolerance in allergy and transplantation, mucosal immunity, T-cell activation and signal transduction and vaccine

Vaccine and Immunotherapy Center (VIC)

Vaccinology and translational research

University of Lausanne UNIL , University Hospital of Lausanne CHUV Ecole Polytechnique Fédérale de Lausanne EPFL, Ludwig Institute for Cancer Research LICR

Swiss Vaccine Research Institute (SVRI)

Immunology, HIV, malaria, TB and cancer vaccine development, of virology and of adjuvant/delivery technology

Sample list of large and small companies in the immunology field in the Bioalps cluster

ABIONIC
IgE allergy diagnosis

INFLAMALPS
Development of anti Tumour Necrosis Factor (TNF) receptor compounds

AC IMMUNE
High affinity ligands and misfolded Abeta protein, SupraAntigenTM Technology and the chemical MorphomerTM platform

MERCK
Novel therapeutic based on drugs modulating pathogenic mechanisms in rheumatologic diseases and autoimmune pathologies

ADC
Antibody drug conjugates (ADCs) for treatment of solid and hematological cancers

NOVIMMUNE
Therapeutic monoclonal antibodies for the treatment of inflammatory diseases and immune-related disorders

ANERGIS
Continuous overlapping peptide (COP) allergy vaccines

PHARMALP
Probiotic nutritional supplements

AUGURIX
IgA and IgG immunochromatography

SHIRE
Immunoglobulins

CSL BEHRING
Plasma-derived products and iotherapies

TRANSCURE BIOSCIENCES
Humanised immune system (HIS) and HIV mouse models

DEBIOPHARM
Drugs for indications in therapeutic areas: immunology, metabolism, infectious diseases

UCB FARCHIM
Innovative medicines and solutions to treat severe diseases of the immune system or of the central nervous system

INCYTE INTERNATIONAL
Therapeutics small molecules for immuno-oncology treatment

VIFOR PHARMA
Fermentation, isolation and purification processes for bacterial products, analytical and immunopharmacological characterisation

The fact sheet provides a view of the key players in the sector at any given time; it is not comprehensive and is subject to regular updates.
This current edition was produced in Spring 2018.