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Discovering the inner workings of the body diagnosis and treatment

Endocrinology is the branch of medicine and biol ogy dealing with the regulation of body functions by hormones and other biochemicals, and the treatment of endocrine system imbalances. It is a complex area of the life sciences that calls on the many disciplines that are present in the Bio Alps cluster. The global market for endocrinology drugs is divided into market segments including: diabetes, growth-hormone, acromegaly and hypogonadism. All of these are growing markets with exciting developments in new molecules, drug formulation and drug delivery systems. The world market for diabetes medications will reach $55.3bn in 20171, the growth hormone mar ket alone is estimated to reach US$ 11.2 billion worldwide by 20182 while the infertility market will reach US$ 1.5 billion by 20173.

Novartis and Sanofi are among the companies within the BioAlps cluster which have developed specific products to manage diabetes. The World Health Organization (WHO), based in Geneva, estimates that diabetes will be the 7th leading cause of death in 2030, with developing coun tries taking on a much greater share of the bur den of disease. Type 1 diabetes is caused by the body’s inability to make insulin, required to regu late glucose content. Type 2 diabetes results from the body’s ineffective use of insulin. People with diabetes require regular monitoring and ongoing treatment to maintain blood sugar levels, creating demand for the development of new micro- and medical technologies, software and drugs to man age the condition better.

The universities and research institutions in the BioAlps have centers of expertise in metabolism, endocrinology and diabetology, spanning basic and applied research, diagnostics and clinical practice. The National Center of Competence in Research (NCCR) “TransCure – From Transport Physiology to Identification of Therapeutic Targets” with the leading house at the University of Bern, seeks to integrate the disciplines of physi ology, structural biology and chemistry to understand how malfunctions in transport proteins and ion channels may contribute to the occurrence of diseases like diabetes, osteoporosis and neurodegeneration.

THE UNIVERSITY HOSPITALS IN GENEVA, LAUSANNE AND BERN ARE AMONG THE FIRST IN THE WORLD TO DEVELOP PATIENT-CENTERED APPROACHES TO THE TREATMENT OF DIABETES, WHETHER FOR OLDER OR YOUNGER PATIENTS.

The BioAlps region is highly innovative, with com petencies across the field of endocrinology and metabolism. Indeed, the first ever recombinant hormone registered, Gonal-F® to treat infertil ity, was developed in the region by Merck Serono who subsequently developed other leading re combinant treatments for infertility. The region hosts another market leader in infertility, Ferring, as well as several start-ups such as PregLem, ac quired by Gedeon Richter, and ObsEva, also spe cialised in women’s reproductive health.

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OBSEVA

Ernest Loumaye co-founded ObsEva in 2012 with industry veteran André Chollet.

ObsEva is a specialty biopharmaceutical company dedicated to the development of innovative drugs for women’s reproductive medicine. Nine months after ObsEva was founded, the company signed a licensing deal from Merck Serono to develop compounds for pre-term labor and concurrently closed a CHF 32 million Series-A financing round (€ 25.6 million).

The Series A financing round was led by Sofinnova Partners, and co-led by Sofinnova Ventures and Novo A/S. Based conveniently in the center of a start-up campus, within easy range of larger companies and research institutions, ObsEva has benefitted from the close proximity in the region of the many experts in drug development, R&D, clinical medicine and finance to prosper at a fast rate.

Research, technical and clinical knowledge all within easy reach in the region

The wealth of knowledge and expertise in the small geographic BioAlps region lie in the research institutions, teaching and research hospitals, and companies, who all collaborate and compete in an environment highly conducive to creating products and opening new market opportunities.

The lists below are non exhaustive and showcase some examples of the work being done in the region.
Find more information in our extensive databases: www.bioalps.org/community and, for the six Alpine regions, www.alpslifesciencesearch.com

Academic institutions at the forefront of endocrinology in western Switzerland

University of Lausanne UNIL
University Hospital of Lausanne
CHUV

Department of Endocrinology, Diabetology and
Metabolism

Pediatric obesity, diabetes and early diagnosis

University of Geneva UNIGE
University Hospitals of Geneva HUG

Department of Medicine Cell Physiology and Metabolism

Experimental models including myocardial infarct, pancreatic islet cells transplantation and diabetes and rheumatoid arthritis

Ecole Polytechnique de Lausanne EPFL

Laboratory of Integrative Systems Physiology LISP

Nuclear and membrane receptors and associated cofactors role in control of metabolic pathways

Laboratory of Computational Systems
Biotechnology LCSB

Genome scale metabolic models

Laboratory for Metabolic and Functional
Imaging LIFMET

Non-invasive measurement of metabolic processes
and function

Geneva Foundation for Medical Education and Research GFMER

WHO Collaborating Centre in Education and Research in Human Reproduction

Sexual health, maternal and child health

Centre suisse d’Electronique et de Microtechnique CSEM

Nanotechnology & Life Sciences

BioMicrosystems – micro-cell reactors, toxicology, biofunctional surface engineering

Systems

Medical devices and health monitoring devices

University of Bern UNIBE

Bern University Hospital INSELSPITAL

Department of Endocrinology, Diabetes and Clinical Nutrition

Obesity, dyslipidaemia (disorders of fat metabolism), bone diseases, neuroendocrine tumours and inherited metabolic diseases

A selection of large and small endocrinology companies in the Bioalps cluster

BIO-UR INTERNATIONAL
Mushroom cultivation for diabetes prevention.

MERCK
Hormones to treat growth deficiencies, infertility from follicular development to early pregnancy, phenylketuronia

DEBIOTECH
Artificial Organs, micro- and nanotechnology, Drug Delivery Systems, Diagnostics and Medical Devices

NOVARTIS
Diabetes

ETHICON
Medical devices and diagnostics to Improve surgical outcomes

OBSEVA
Drugs to prevent pre-term birth, to enhance embryo implantation following ART and treat dysmenorrhea

ELI LILLY (SUISSE)
Drugs for the treatment of several additional growth disorders and for growth hormone deficiency in adults

PREGLEM
Selective progesterone receptor modulator (SPRM); steroid sulfatase inhibitor (STS-I); Somatostatin Antagonist; c-Jun-N-Terminal Kinase Inhibitor for women’s reproductive health

FERRING
Hormones for obstetrics, fertility, gynecology and growth deficiency.

SANOFI
Diabetes and CNS products

GLAXOSMITHKLINE
Diabetes

SERVIER
Drugs for treatment of diabetes

GENKYOTEX NOX
Enzyme inhibitors for metabolic disorders

VIFOR PHARMA
Menopause and women’s health

The fact sheet provides a view of the key players in the sector at any given time; it is not comprehensive and is subject to regular updates.
This current edition was produced in Spring 2018.