UNIGE and UNIL : “A model to decipher the complexity of gene regulation”
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Scientist at the Universities of Geneva and Lausanne, Switzerland, designed a framework to analyse gene regulation, and offer a model to better understand the role of the non-coding portion of the genome in disease risk.
More than genes themselves, how, where and when they are expressed determine our biological traits – our phenotypes. If gene expression is controlled by many regulatory elements, what, ultimately, controls those? And how does genetic variation affect them? The SysGenetiX project, led by the University of Geneva (UNIGE) in collaboration with the University of Lausanne (UNIL), Switzerland, precisely aimed to investigate these regulatory elements, as well as the manifold interactions between them and with genes, with the ultimate goal of understanding the mechanisms that render some people more predisposed to manifesting particular diseases than others.